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Early Colorectal Cancer Treated by Endoscopic Mucosal Resection
Mon - May 9, 2011 9:51 am  |  Article Hits:3800  |  A+ | a-
Methods 129 early colorectal cancer (ECC) patients who were initially treated by EMR between April 2005 and August 2007 were enrolled. Clinicopathological characteristics and prognosis were evaluated retrospectively. Results En-bloc resection was performed in 85% of ECC patients and piece-meal resection in 15% of patients. Clear lateral and deep margins achieved in 86% of cases. Of 129 patients, 64 showed intramucosal cancer and 65 submucosal cancer. Clinical characteristics were not different between patients with intramucosal cancer and submucosal cancer, however, poor-differentiation and the absence of background adenoma showed significant association with submucosal cancer.

7 patients with submucosal cancer underwent subsequent surgical resection; 5 had lymphovascular invasion or positive resection margin, 1 perforation, and 1 patient's request. Of these 7 patients, 1 had residual cancer and 2 had lymph node metastasis. All patients with intramucosal cancer showed no recurrence during the follow-up period. 7 patients with submucosal cancer showed adverse outcomes within 3 years, such as residual/recurrence of primary cancer or lymph node metastasis; 5 showed lymphovascular invasion or positive deep margin, and 2 had no histological risk factors.

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