Free Medical Advice | Asesoramiento médico gratuito| मुफ्त चिकित्सा सलाह

suspicion of t cell lymphoma complication of coeliac disease
Discussion in 'All Categories' started by raj - Jul 24th, 2012 1:47 pm.
check up full area from stomach to colon and lymph nodes and resection or full thickness biopsy of the small intestine disease mostly in jejunum and ileum.
re: suspicion of t cell lymphoma complication of coeliac disease by Dr M K Gupta - Jul 29th, 2012 3:40 am
Dr M K Gupta
Dr M K Gupta
Dear Raj,

One severe complication of coeliac disease is enteropathy-associated T cell lymphoma, a high-grade invasive lymphoma with a inadequate prognosis. Previous studies have suggested that chronic exposure of immune cells in the walls from the small intestine, which are known as intraepithelial lymphocytes, to potent anti-death signals initiated by the soluble factor IL-15 plays a role in the development of enteropathy-associated T cell lymphoma. Molecular biological and immunohistochemical research indicates the intestinal mucosa distant from the tumour contains clonal populations of small T cells, often of the same clone as the high-grade T-cell lymphoma. These findings suggest that enteropathy-associated T-cell lymphoma arises in the setting of coeliac disease and evolves from reactive intraepithelial lymphocytes through a low-grade lymphocytic neoplasm to a high-grade tumour, which is usually cause of the presenting symptoms. Most cases of chronic ulcerative enteropathy (ulcerative jejunitis) are most likely part of the same disease process. When the ulceration occurs at any given time once the neoplastic T-cells are of a poor quality, morphological recognition of tumour cells within the ulcers may be impossible.

Adherence to a strict GFD is fully necessary in lessening the chance of developing CD complications, and its protective effect was shown a lot more than Two decades ago; previously few years, many papers have addressed this issue, confirming its importance

The suspicion of EATL should lead to an extensive diagnostic workup in which MR enteroclysis, coupled with PET scan and histologic identification of lesions, represents the best options. The best current treatment choice is high-dose chemotherapy, preceded by surgical resection and then ASCT, although this process could simply be put on a strictly selected quantity of patients able to tolerate it. Further research is required to verify whether innovative therapies might be of help in treating or preventing EATL. Strict adherence to some GFD remains the best option to avoid EATL in patients with CD.

So in our opinion you need thorough diagnosis first and according to that corrective measure has to be taken.

With regards

M K Gupta

With regards

Post Reply
Name *
Email * Will be hidden from visitors
Your Picture * Limit 2Mb please
Enter verification code Mathematical catpcha image
- calculate the result
* - required fields


Get Free Postoperative Advice

Laparoscopic Surgery Training

If you have a surgical concern and can’t reach a doctor right away, or you’re not sure where else to ask a qualified laparoscopic surgeon, you can get our Medical Help through this Forum of World Laparoscopy Hospital which is available 24 hours a day, Just fill-up the form given and within few our the answer of your question will be posted on this forum. Please keep in mind we answer the question only related to laparoscopic surgery. You can also search and browse thousands of answer already posted on this forum

Using Free Medical Advice Related to Laparoscopic Surgery Service, you can send your questions to our Laparoscopic Surgeon and the Doctor will reply within few hour. It’s as if you are having an email exchange with your very own private surgeon! As soon as you post your question, a qualified laparoscopic surgeon will start answering it. Our expert can help you learn more about the treatment and procedure options available to you for different health problems and diseases.They’ll also give you information to discuss with your doctor when deciding what kind of surgical treatment is best for you.

The Doctor will provide you with the all the medical information you need, and will guide you as you choose a course of action, all from the comfort of your home or office. No more sitting in the waiting room for hours just to get some basic information from your laparoscopic surgeon; no more self-diagnosis after reading pages and pages of confusing and contradictory Online information.

World Laparoscopy Hospital gives you the personalized health information you need to decide on the right treatment for you. The information that you provide will be seen by every person for education and information purpose so please not write your real name.

In case of any problem in asking free medical advice please contact | RSS

World Laparoscopy Hospital, Cyber City, Gurugram, NCR Delhi, 122002, India

All Inquiries

Tel: +91 124 2351555, +91 9811416838, +91 9811912768, +91 9999677788

Need Help? Chat with us
Click one of our representatives below
Hospital Representative
I'm Online