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Over dosage of vitamin A and D
Discussion in 'All Categories' started by samir - Mar 7th, 2013 4:52 am.
Dear doctor,
I have decided to take shark liver oil because I have heard it is good for cold. When i ask shark liver oil capsules form pharmacy they give me vitamin A and D capsules that capsules also looking same as shark liver oil capsules same colure same look. A capsule integrates both vitamin A and D, it label as vitamin A and D. I decided to take 6 capsules in daily because that capsules are very small they said it give for little kids .i take that capsules near to 2 months Finally I have count how much capsules I have taken in that period? 216 capsules have taken in that few days.
Before 3 weeks ago I have feeling bad pain in my left eye and also it gone around the left side of the head. I was getting wonder! What happen suddenly to my left eye because my visions have no problem. I have good vision so I went to eye clinic , clinic doctor give me eye drop but it not give me any good result it not reduce that bad pain.
Finally I have decided to stop taking vitamin A and D capsules. 2 days a after stop it I have feeling good no any pain in my left eye. After I search in internet about side effect of vitamin A and D. most of medicine site said over dosage of vitamin A and D have horrible side effects so I
re: Over dosage of vitamin A and D by Dr J S Chowhan - Mar 7th, 2013 11:58 am
Dr J S Chowhan
Dr J S Chowhan
Dear Samir

Upper limit to get a substance could be the amount as much as that is considered safe and without probability of adverse effects within the majority of the population.

Toxicity threshold for a substance could be the amount beyond which over-saturation occurs and signs of toxicity manifest.

These values for 25(OH)D are highlighted below:

Toxicity threshold level - 200-250 ng/mL (500-750 nmol/L. Maximum - 100 ng/mL (250 nmol/L)
The massive consist of 25(OH)D maximum as well as threshold value implies a qualification of safety at serum levels up to 100 ng/mL (250 nmol/L), since concentrations twice this amount have not yet ever be associated with toxicity.

In animal models, serum concentrations have reached of up to 400-700 ng/mL (1,000-1750 nmol/L) before toxic effects (severe hypercalcemia) were observed. The 1st indication of vitamin D toxicity is hypercalcuria (excess calcium within the urine) then hypercalcemia (high calcium). The subsequent symptoms may present:

poor appetite
constipation (possibly alternating with diarrhea)
weight reduction
tingling sensations from the mouth
heart rhythm abnormalities
The immediate the signs of vitamin D overdose are:

abdominal cramps

Right off the bat is to stop supplementation, then have your physician enable you to decide if you are toxic by testing your 25(OH)D levels. This is actually the same test accustomed to determine vitamin D deficiency.

If your results show a serum 25(OH)D level of 200-250 ng/mL (500-750 nmol/L) or more, you will be toxic. The subsequent measures needs to be taken until vitamin D levels resume normal:

avoidance of sunshine exposure
avoidance of foods and supplements containing vitamin D
restriction of calcium intake
drinking 8 servings of water daily
Once 25(OH)D levels have normalized, sunlight exposure and/or vitamin D supplementation could be resumed, the constant maintenance to not overdo it.

In most cases, vitamin D toxicity may be corrected without lasting problems, provided our bodies has not yet remained in a hypercalcemic state for too long. Hypercalcemia can cause soft tissue calcification, resulting in deposits of calcium crystals from the heart, lungs, and/or kidneys. With prolonged hypercalcemia, permanent damage is possible if calcification is severe enough.

With regards

J S Chowhan
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