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suspicion of enteropathy associated t cell lymphoma
Discussion in 'All Categories' started by raj - Jul 24th, 2012 1:52 pm.
diagnostic thearaptic laproscopy with full thickness biopsy of the intestine or resection and mesentric lymph node. check from full stomach to colon and other abdominal organs. abdominal pain, diarhea and refractory celiac disease.
re: suspicion of enteropathy associated t cell lymphoma by Dr M K Gupta - Jul 29th, 2012 3:43 am
Dr M K Gupta
Dr M K Gupta
Dear Raj

One severe complication of celiac disease is enteropathy-associated T cell lymphoma, a high-grade invasive lymphoma with a very poor prognosis. Previous research has suggested that chronic exposure of immune cells in the walls of the small intestine, that are known as intraepithelial lymphocytes, to potent anti-death signals initiated through the soluble factor IL-15 contributes to the development of enteropathy-associated T cell lymphoma. Molecular biological and immunohistochemical studies have shown that the intestinal mucosa distant in the tumour contains clonal populations of small T cells, often of the same clone because the high-grade T-cell lymphoma. These bits of information claim that enteropathy-associated T-cell lymphoma arises within the setting of coeliac disease and evolves from reactive intraepithelial lymphocytes via a low-grade lymphocytic neoplasm to some high-grade tumour, that is usually reason for the presenting symptoms. Most cases of chronic ulcerative enteropathy (ulcerative jejunitis) are most likely area of the same disease process. When the ulceration occurs at a time once the neoplastic T-cells are of the low grade, morphological recognition of tumour cells in the ulcers may be impossible.

Adherence to a strict GFD is fully necessary in reducing the chance of developing CD complications, and its protective effect was shown a lot more than Two decades ago; previously few years, many papers have addressed this problem, confirming its importance

The suspicion of EATL should lead to a comprehensive diagnostic workup in which MR enteroclysis, coupled with PET scan and histologic identification of lesions, represents the best options. The best current treatment option is high-dose chemotherapy, preceded by surgical resection and followed by ASCT, even though this process could only be applied to a strictly selected number of patients in a position to tolerate it. Further studies are required to verify whether innovative therapies might be of assist in treating or preventing EATL. Strict adherence to a GFD continues to be best option to avoid EATL in patients with CD.

With regards
M.K. Gupta
re: suspicion of enteropathy associated t cell lymphoma by Pintugamit - Aug 7th, 2012 7:13 am
A book of poetry? Cool! Gallbladder serrugy and then home the same day? Wow. I'm not good with the heels, but I wear skirts all the time because they are breezy and easier on my waistline than shorts. ;D I hope you don't break a nail often. I will do this meme, but I don't think that I know that many bloggers yet. I will do my best. Thanks for thinking of me!
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