|Discussion in 'All Categories' started by Dr Mahati Varma - Sep 15th, 2013 8:48 am.|
Dr Mahati Varma
|Calcified cyst/stromal tumour based at oesophgus above ge junction in 9yr old boy (incidental finding)|
re: Calcified cyst/stromal tumour by Dr J S Chowhan - Sep 25th, 2013 7:52 pm
Dr J S Chowhan
|Dear Dr Varma
First we have to confirm the stromal tumour. The most commonly used marker for GIST is the CD117 antigen, a marker expressed by ICC. Approximately 95% of GISTs are positive for the CD117 antigen, an epitope of the KIT receptor tyrosine kinase. However, CD117 immunohistochemistry is not specific for GIST, as weak reactivity occurs with other mesenchymal neoplasms; accordingly, morphologic examination and the use of other immunostains in difficult cases are indispensible. In addition, false-positive CD117 staining can occur if antigen retrieval techniques are used in the pathology laboratory to enhance marker expression. Because of a relatively broad morphologic spectrum, the differential diagnosis of GIST includes several mesenchymal, neural, and neuroendocrine neoplasms that occur in the abdomen.
Please get a thorough investigation done to find out the pathology. You can bring your son to see one endocrinologist and after that we can make the things clear.
J S Chowhan
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