|Discussion in 'All Categories' started by Maria De Pinho - Mar 19th, 2014 7:50 pm.|
Maria De Pinho
|Female 55 years old with pedunculated subserosal fibroid, (very vascular).Uterus normal.Diagnosed acromegaly .Operated in 1989 for pituitary tumor.I want to avoid histiocytoma .I have and I can send The MRI by drop box.I have IGF-1 (grow factor )287.
May I send you the MRI?Can you tell me if laparoscopy is a good option to me?
Many thanks. I wait your answer .m.Paula
re: Pedunculated subserosal fibroid 12 cm(only one) by Dr.J S Chowhan - Mar 22nd, 2014 4:01 pm
Dr.J S Chowhan
|Dear Maria De Pinho
Laparoscopic Myomectomy is the best option for you.Incidence of Histiocytoma is high in patients with acromegaly with high GF.The skin has the necessary elements to respond to growth hormone (GH) and suffers clinical changes in the pathological circumstances of excess and deficiency of GH. The GH has been involved in the development of different types of human neoplasms. Based on these data, scientists have studied the GH receptor (GHR) expression in acrochordons, seborrheic keratosis, melanocytic nevi, histiocytomas, squamous cell carcinomas, basal cell carcinomas, and malignant melanomas by means of the immunohistochemistry with the monoclonal antibody MAb 263. All the entities showed immunoreactivity for GHR. In the histiocytomas, the expression of GHR in the keratinocytes of the hyperplastic epidermis coating the lesion showed a strong nuclear pattern, but the non-hyperplastic epidermis of the edges of the histiocytomas expressed GHR with a cytoplasmic pattern. In the basal cell carcinoma and squamous cell carcinoma, the immunoreactivity was weaker than in normal skin. In the squamous cell carcinoma, the intensity of immunostaining correlated directly with the grade of cellular differentation. In conclusion, the GH may be involved in the development of different kinds of cutaneous neoplasms, and the intracellular localization of GHR may imply a functional significance, at least in the histiocytomas.You please send your MRI and other reports and then we can advice further and even decide on date of surgery.
Dr J S Chowhan
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