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liver chronic rejection (chirosis) , this happen ,within 1week after liver transplantation.
Discussion in 'All Categories' started by sivakumar - Sep 2nd, 2012 12:57 am.
respected, doctor,my sister son have liver chronic rejection , within 1 week after liver transplant,now doctors say,again do liver transplant for my sister son.but liver donor is my sister ,give liver to her son,but why the liver transplant is not success?.and then now,my sister son, cannot eat,drink,&no pass motion, always sleeping,& some times shouting why happen like this doctor.?,
re: liver chronic rejection (chirosis) , this happen ,within 1week after liver transplantation. by Dr M K Gupta - Sep 2nd, 2012 6:25 am
Dr M K Gupta
Dr M K Gupta
Dear Sivakumar

Rejection of a liver after transplant occurs because the recipient's cells recognize the donor's cells as foreign and attack the new liver. Immunosuppressant medications are given after transplant to keep the immune system from attacking the new organ's cells, but rejection may still occur. Up to 75 percent of all liver transplant recipients experience at least one bout with rejection, usually within the first two months after transplant.

If rejection is suspected, the transplant physician needs to be involved early in the course for evaluation and management. Despite improvements in immunosuppressive therapy, hepatic allograft rejection remains an important cause of morbidity and late graft loss in patients undergoing liver transplantation.

Early acute cellular rejection mostly occurs within 90 days of the liver transplantation. Early acute rejection episodes do not adversely affect graft or patient outcomes, except in patients transplanted for hepatitis C virus, who have worse outcomes in the setting of bolus glucocorticoid therapy. Late cellular rejection episodes are often associated with low blood cyclosporine or tacrolimus concentrations and have been associated with reduced graft survival.

So in our opinion please discuss these issues with your transplant surgeon and then try to get the second surgery done with extreme precaution.

With regards
MK Gupta
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