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Discussion in 'All Categories' started by Esther Kogo - Dec 11th, 2011 5:03 pm.
Esther Kogo
Esther Kogo
My mother named above was diagnosed with an abdominal tumour.From the MRI report it is classified as either a fibrosarcoma or Liposarcoma.It measures 11.5cm by 10.7cm by 12.5cm.
re: CANCEROUS TUMOUR by Dr M K Gupta - Dec 11th, 2011 9:22 pm
Dr M K Gupta
Dr M K Gupta
Dear Esther Kogo

We need to examine your mother thoroughly to decide that surgery is feasible or not.

Liposarcoma is a malignancy of fat cells. Fibrosarcoma is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells. In adults, it's the most typical soft tissue sarcoma. Liposarcoma normally appears as a slowly enlarging, painless, nonulcerated submucosal mass in a middle-aged person, however, many lesions grow rapidly and become ulcerated early. Virchow first described liposarcoma in the 1860s.

The development of a liposarcoma from the preexisting benign lipoma is rare. Many instances arise de novo. Liposarcomas most often arise in the deep-seated stroma as opposed to the submucosal or fat under the skin. The most recent World Health Organization classification of soft tissue tumors recognizes 5 types of liposarcomas: (1) well differentiated, including the adipocytic, sclerosing, and inflammatory subtypes; (2) dedifferentiated; (3) myxoid; (4) round cell; and (5) pleomorphic.

A spindle-cell variant of well-differentiated liposarcoma can also be described. The notion that round-cell liposarcoma represents the high-grade counterpart of myxoid liposarcoma is generally accepted. Spindle-cell liposarcoma is a rare variant of the atypical lipomatous tumor (ie, well-differentiated liposarcoma), also it must be distinguished from a dedifferentiated liposarcoma with metastatic potential along with a benign spindle-cell lipoma. The advent of cytogenetic and molecular investigations has contributed to better categorization of the subset of mesenchymal neoplasms. Not just they have provided new insights in to the biology of these tumors, however they also have validated the present classification schemes according to conventional morphologic observations.

Liposarcoma occurs in 3 main biologic forms: (1) well-differentiated liposarcoma; (2) myxoid and/or round cell; and (3) pleomorphic. In rare circumstances, lesions can have a combination of morphologic types; they are classified as combined or mixed-type liposarcomas.

The anatomical distribution of liposarcoma appears to be partly related to the histologic type. Well-differentiated liposarcoma tends to exist in deep soft tissues of both the limbs and also the retroperitoneum. Myxoid and/or round-cell liposarcomas and pleomorphic liposarcomas have a striking predilection for that limbs, and dedifferentiated liposarcoma occurs predominantly within the retroperitoneum. Although any liposarcoma subtype occasionally arises within the subcutis, involvement from the dermis seems to be exceedingly rare.

Surgery is possible in early stages and if it has not spread extensively.

With regards

M.K. Gupta
re: CANCEROUS TUMOUR by Welcome - Jun 1st, 2012 5:42 am
I appreciate you taking to time to cnotribute That's very helpful.
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