Granulosa cell tumor - is it cancer? One dr says no!
| Discussion in 'All Categories' started by Amy Hinds-Alvarado - May 8th, 2012 8:45 pm. | |
Amy Hinds-Alvarado
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I had laparoscopy last month and during removal of tumor it ruptured. Pathologist says it is a granulosa cell tumor pT1C pNX pM (not applicable). Gross description says received fresh from OR, 8.0 x 6.0 x 2.0 cm aggregate of irregular, fragmented, friable tan pink soft tissues. One aspect is glistening, and the opposite aspect is friable and papillary. No distinction between internal or external surfaces can be made. Microscopic description says sections demonstrate a neoplasticism proliferation of small cells women chromatin and grooved nuclei forming diffuse sheets and trabecular arrangements. A suggestion of rare rosette-like structures is also noted. Findings are morphological lay consistent w a granulosa cell tumor, adult. Immunohistochemical stains show the neoplasticism cells to express Inhibin, Calretinin, and PR. Immunostain for ER shows very focal, weak staining. Immunostains for CK AE 1/3, Synaptophysin, and Chromogrannin are negative. Immunophenotypicnfindings support the morphological impression. Permanent sections confirm the frozen section report. 1st gyo oncologist recommends hysterectomy, remove both ovaries and tubes, omentum lower, check lymph nodes, other areas for cells. He told me it is cancer. 2nd doctor told me he doesn't know if it is cancer after looking thru report and only recommends removal of left ovary and tube. Isn't granulosa cell tumor cancer? What would you recommend I have done? Neither dr recommended chemo. I am confused by the no cancer statement. Should I do hormone replacement therapy after full hysterectomy? I am 38 years. Thank you. |
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re: Granulosa cell tumor - is it cancer? One dr says no!
by Dr J S Chowhan -
May 10th, 2012
1:58 pm
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Dr J S Chowhan
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Dear Madam Actually Granulosa cell tumor (GCT) of the ovary is a hormonally active, stromal cell cancer that is distinguished by its ability to secrete sex steroids such as estrogen. The value of postoperative adjuvant therapy for high-risk patients has not been investigated by prospective randomized trials, which are difficult to perform because of the rarity of this tumor. Nonetheless, the use of adjuvant chemotherapy or radiation has sometimes been associated with prolonged disease-free survival in patients with high-risk features. Because of the propensity of GCT to recur years after initial diagnosis, prolonged surveillance with serial physical examination and serum tumor markers such as estradiol and inhibin is reasonable. Type of adjuvent therapy after surgery will be guided to you by surgeon who will perform this surgery. According to severity of disease. With regards J S Chowhan |
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re: Granulosa cell tumor - is it cancer? One dr says no!
by spidgerge -
May 11th, 2012
3:13 pm
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spidgerge
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Howdy momis! |
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re: Granulosa cell tumor - is it cancer? One dr says no!
by Herman -
Jun 1st, 2012
1:47 am
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Herman
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You probably shluod see a doctor. Chances are that the surgeon cut into some nerves when the lipoma was removed. That can take a long time to heal. If it is hurting again, I would check with a doctor. The discomfort shluod get less, not more. |
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re: Granulosa cell tumor - is it cancer? One dr says no!
by DougBah -
Dec 19th, 2013
7:58 am
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DougBah
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I am writing a paper about Art Movements of the 20th Century, does anyone have suggestion for authoritive resources? |